Molecular Targeting Technologies國(guó)內(nèi)代理Target Technology。Duramycin (Moli1901) 是一種來(lái)源于 Streptomyces cinnamoneuma 的羊毛硫細(xì)菌素。Duramycin 也是一種抗菌肽。Duramycin 可用于囊性纖維化（CF）的研究。熒光素CY5偶聯(lián)Duramycin：Duramycin-Cy5 Fluorescent Conjugate（貨號(hào)：D-1002），通過(guò)偶聯(lián)熒光素，我們可以流式或者免疫熒光檢測(cè)。甚至可以動(dòng)態(tài)監(jiān)測(cè)。
| 生物活性 | Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF). | ||||||||||
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| 體內(nèi)研究 (In Vivo) | Evaluation of [68Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [68Ga]NODAGA-Duramycin. [68Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice. These methods are for reference only. | ||||||||||
| Clinical Trial |
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| 分子量 | 2013.28 | ||||||||||
| Formula | C89H125N23O25S3 | ||||||||||
| CAS 號(hào) | 1391-36-2 | ||||||||||
| 性狀 | 固體 | ||||||||||
| 外觀(guān)顏色 | White to off-white | ||||||||||
| Sequence | Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe--Phe-Val-Cys-Asp-Gly-Asn--Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11) |
Product Description:
A Cy5 dye is attached to amino groups of duramycin. The conjugate contains 1 Cy5 dye molecule per duramycin molecule. Duramycin binds phosphatidylethanolamine (PE) at a 1:1 ratio with high affinity (Kd of 4-6 nM) and exclusive specificity. Properties of Duramycin-Cy5 。
Molecular Targeting Technologies熒光素CY5偶聯(lián)Duramycin產(chǎn)品說(shuō)明書(shū)
產(chǎn)品名稱(chēng)：Duramycin-Cy5 Fluorescent Conjugate
貨號(hào)：D-1002
規(guī)格：132ugrams
代理：Targeting Technology（靶點(diǎn)科技）
溶解方法：
向小瓶中加入200uL 1%DMSO水溶液，用移液器上下吸液以溶解固體，得到就是250uM的含1%DMSO的水溶液。
靶點(diǎn)科技（北京）有限公司
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